Philosophy 4140
Current Debates in the
Philosophy of Science
Fall 2017

Place: Alexander Hall 309                         
Monday & Wednesday
2:30-3:50


Instructor:
Stefan Linquist
        


Email:
linquist@uoguelph.ca                  

Office: MacKinnon 358
Office Hours:  Wednesday 

4:00-5:00

                         
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Course Materials                                                                                                 

             Syllabus  (pdf)      
                 
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Readings
Available through the bookstore:





Available through ARES:

Doucet, Andrea and Mauthner, Natasha (2002), “Knowing Responsibly: Linking Ethics, Research Practice and Epistemology.” In Ethics in Qualitative Research, Melanie Mauthner, Maxine Birch, Julie Jessop, and Tina Miller (eds). London: Sage.

Comfort, Nathaniel  (1995). 'Two genes, no enzymes: A second look at Barbara Mcclintock and the 1951 Cold Spring harbour symposium." Genetics, 140, 1161–1166.

Comfort, Nathaniel (1999). “'The real point is control': The reception of Barbara Mcclintock’s controlling elements." Journal of the History of Biology, 32(1), 133–162.

Orgel, Leslie A. and Crick, Francis (1980, "Selfish DNA: the ultimate parasite." Nature 284: 604-607.

Doolittle, W. Ford and Sapienza, Carmen (1980), "Selfish genes, the phenotype paradigm and genome evolution." Nature, 284: 601-603.

Doolittle, W. Ford(1982), "Selfish DNA after fourteen months." In Genome Evolution (ed. G.A. Dover and Flauvell), Academic Press: New York (p. 3-28).

Tauber, Alfred and Sarkar, Sahotra (1992), "The Human Genome Project:Has blind reductionism gone too far?" Perspectives in Biology and Medicine  35:220-235.

Garcia-Sancho, Miguel (2006), "The rise and fall of the idea of genetic information (1948-2006)" genomics, Society and Policy 2: 16-36.

Rosenberg, Alex (2007), “Is Epigenetic Inheritance a Counterexample to the Central Dogma? History and Philosophy of the Life Sciences, Vol. 28, (4): 549-565.

Hayden, Erica, 2010, “Human Genome at Ten: Life is Complicated”, Nature, 464(7289): 664–667.

Keller, E.F. (2014) From gene action to reactive genomes. The Journal of physiology, 592(11), 2423-2429.

Doolittle, W. Ford (2012), "is junk DNA bunk? A critique of ENCODE." Proceedings of the National Academy of Science USA 110: 5294-5300.

Leonelli, Sabina, 2014, “What Difference Does Quantity Make? on the Epistemology of Big Data in Biology”, Big Data & Society, 1.

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Supplementary
Dupré, John, 2004, “Understanding Contemporary Genomics,” Perspectives on Science, 12: 320–338

Powell, Alexander, O’Malley, Maureen, Müller-Wille, Staffan (2007),  “Disciplinary Baptisms: A Comparison of the Naming Stories of Genetics, Molecular Biology, Genomics, and Systems Biology.” History and Philosophy of the Life Sciences, 29: 5-32.

Piotrowska, Monika, 2009, “What Does it Mean to be 75% Pumpkin? The Units of Comparative Genomics”,
Philosophy of Science, 76(5): 838–850.

O’Malley, Maureen A., Kevein C. Elliott, and Richard M. Burian, 2010, “From Genetic to Genomic Regulation: Iterativity in MicroRNA Research”, Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 41(4): 407–417.

Sboner, A., X.J. Mu, D. Greenbaum, R.K. Auerbach, and M.B. Gerstein, 2011, “The Real Cost of Sequencing: Higher Than You Think”, Genome Biology, 12(8): 125.

Eisen, Jonathan A., 2012, “Badomics Words and the Power and Peril of the ome-meme”,GigaScience, 1(1): 6.

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Resources
Barbara McClintock's talk at the Nobel award ceremony on Dec, 8, 1983.

A short animation of DNA transposition.

Another good explanation of transposable elements. 

Fantastic talk by Sue Wessler describing tranposon activity in rice.